Germinal center B cells govern their own fate via antibody feedback

Affinity maturation of B cells in germinal centers (GCs) is a process of evolution, involving random mutation of immunoglobulin genes followed by natural selection by T cells. Only B cells that have acquired antigen are able to interact with T cells. Antigen acquisition is dependent on the interacti...

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Bibliografiske detaljer
Main Authors: Zhang, Yang, Meyer-Hermann, Michael, George, Laura A., Figge, Marc Thilo, Khan, Mahmood, Goodall, Margaret, Young, Stephen P., Reynolds, Adam, Falciani, Francesco, Waisman, Ari, Notley, Clare A., Ehrenstein, Michael R., Kosco-Vilbois, Marie, Toellner, Kai-Michael
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2013
Fag:
Brief Definitive Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600904/
https://ncbi.nlm.nih.gov/pubmed/23420879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120150
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