Myeloid loss of Beclin 1 promotes PD-L1(hi) precursor B cell lymphoma development

Beclin 1 (Becn1) is a key molecule in the autophagy pathway and has been implicated in cancer development. Due to the embryonic lethality of homozygous Becn1-deficient mice, the precise mechanisms and cell type–specific roles of Becn1 in regulating inflammation and cancer immunity remain elusive. He...

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Udgivet i:J Clin Invest
Main Authors: Tan, Peng, He, Lian, Xing, Changsheng, Mao, Jingrong, Yu, Xiao, Zhu, Motao, Diao, Lixia, Han, Leng, Zhou, Yubin, You, M. James, Wang, Helen Y., Wang, Rong-Fu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877338/
https://ncbi.nlm.nih.gov/pubmed/31503548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127721
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