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Sonic Hedgehog repression underlies gigaxonin mutation–induced motor deficits in giant axonal neuropathy
Growing evidence shows that alterations occurring at early developmental stages contribute to symptoms manifested in adulthood in the setting of neurodegenerative diseases. Here, we studied the molecular mechanisms causing giant axonal neuropathy (GAN), a severe neurodegenerative disease due to loss...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6877328/ https://ncbi.nlm.nih.gov/pubmed/31503551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI129788 |
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