Sonic Hedgehog repression underlies gigaxonin mutation–induced motor deficits in giant axonal neuropathy

Growing evidence shows that alterations occurring at early developmental stages contribute to symptoms manifested in adulthood in the setting of neurodegenerative diseases. Here, we studied the molecular mechanisms causing giant axonal neuropathy (GAN), a severe neurodegenerative disease due to loss...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Arribat, Yoan, Mysiak, Karolina S., Lescouzères, Léa, Boizot, Alexia, Ruiz, Maxime, Rossel, Mireille, Bomont, Pascale
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877328/
https://ncbi.nlm.nih.gov/pubmed/31503551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI129788
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