Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response

microRNA-21 (miR-21) is the most commonly upregulated miRNA in solid tumors. This cancer-associated microRNA (oncomiR) regulates various downstream effectors associated with tumor pathogenesis during all stages of carcinogenesis. In this study, we analyzed the function of miR-21 in noncancer cells o...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Sahraei, Mahnaz, Chaube, Balkrishna, Liu, Yuting, Sun, Jonathan, Kaplan, Alanna, Price, Nathan L., Ding, Wen, Oyaghire, Stanley, García-Milian, Rolando, Mehta, Sameet, Reshetnyak, Yana K., Bahal, Raman, Fiorina, Paolo, Glazer, Peter M., Rimm, David L., Fernández-Hernando, Carlos, Suárez, Yajaira
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877327/
https://ncbi.nlm.nih.gov/pubmed/31710308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127125
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