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Pharmacological methods to transcriptionally modulate double-strand break DNA repair

There is much interest in targeting DNA repair pathways for use in cancer therapy, as the effectiveness of many therapeutic agents relies on their ability to cause damage to DNA, and deficiencies in DSB repair pathways can make cells more sensitive to specific cancer therapies. For example, defects...

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Detalles Bibliográficos
Publicado en:Int Rev Cell Mol Biol
Autores principales: Kaplan, Alanna R., Glazer, Peter M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577782/
https://ncbi.nlm.nih.gov/pubmed/32475473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.ircmb.2019.11.003
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