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Dative Directing Group Effects in Ti-Catalyzed [2+2+1] Pyrrole Synthesis: Chemo- and Regioselective Alkyne Heterocoupling

Transient dative substrate–Ti interactions have been found to play a key role in controlling the regioselectivity of alkyne insertion and [2+2] cycloaddition in Ti-catalyzed [2+2+1] pyrrole synthesis and Ti-catalyzed alkyne hydroamination. TMS-protected alkynes with pendent Lewis basic groups can in...

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Detalhes bibliográficos
Publicado no:ACS Catal
Main Authors: Chiu, Hsin-Chun, See, Xin Yi, Tonks, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876699/
https://ncbi.nlm.nih.gov/pubmed/31768294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.8b04669
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