Semimechanistic Pharmacodynamic Modeling of Aztreonam‐Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug‐Resistant Gram‐Negative Bacteria

Aztreonam‐avibactam (ATM‐AVI) is a promising combination to treat serious infections caused by multidrug‐resistant (MDR) pathogens. Three distinct mechanisms of action have been previously characterized for AVI: inhibition of ATM degradation by β‐lactamases, proper bactericidal effect, and enhanceme...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:CPT Pharmacometrics Syst Pharmacol
Prif Awduron: Chauzy, Alexia, Gaelzer Silva Torres, Bruna, Buyck, Julien, de Jonge, Boudewijn, Adier, Christophe, Marchand, Sandrine, Couet, William, Grégoire, Nicolas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2019
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876579/
https://ncbi.nlm.nih.gov/pubmed/31420947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12452
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