Sequential Time-Kill, a Simple Experimental Trick To Discriminate between Pharmacokinetics/Pharmacodynamics Models with Distinct Heterogeneous Subpopulations versus Homogenous Population with Adaptive Resistance

Experiments were conducted with polymyxin B and two Klebsiella pneumonia isogenic strains (the wild type, KP_WT, and its transconjugant carrying the mobile colistin resistance gene, KP_MCR-1) to demonstrate that conducting two consecutive time-kill experiments (sequential TK) represents a simple app...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Chauzy, A., Ih, H., Jacobs, M., Marchand, S., Grégoire, N., Couet, W., Buyck, J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526804/
https://ncbi.nlm.nih.gov/pubmed/32513802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00788-20
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