Semimechanistic Pharmacokinetic-Pharmacodynamic Model with Adaptation Development for Time-Kill Experiments of Ciprofloxacin against Pseudomonas aeruginosa

The objective of this study was to implement a semimechanistic pharmacokinetic-pharmacodynamic (PK-PD) model to describe the effects of ciprofloxacin against Pseudomonas aeruginosa in vitro. Time-kill curves were generated with an initial inoculum close to 5 × 10(6)CFU/ml of P. aeruginosa PAO1 and c...

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Main Authors: Grégoire, Nicolas, Raherison, Sophie, Grignon, Claire, Comets, Emmanuelle, Marliat, Manuella, Ploy, Marie-Cécile, Couet, William
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Assuntos:
Experimental Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876392/
https://ncbi.nlm.nih.gov/pubmed/20368392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01478-08
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