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Molecular dynamics simulations of aptamer-binding reveal generalized allostery in thrombin
Thrombin is an attractive target for antithrombotic therapy due to its central role in thrombosis and hemostasis as well as its role in inducing tumor growth, metastasis, and tumor invasion. The thrombin-binding DNA aptamer (TBA), is under investigation for anticoagulant drugs. Although aptamer bind...
Sparad:
| I publikationen: | J Biomol Struct Dyn |
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| Huvudupphovsmän: | , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2016
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6876308/ https://ncbi.nlm.nih.gov/pubmed/27794633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/07391102.2016.1254682 |
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