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Unfolding mechanism of thrombin-binding aptamer revealed by molecular dynamics simulation and Markov State Model
Thrombin-binding aptamer (TBA) with the sequence 5′GGTTGGTGTGGTTGG3′ could fold into G-quadruplex, which correlates with functionally important genomic regionsis. However, unfolding mechanism involved in the structural stability of G-quadruplex has not been satisfactorily elucidated on experiments s...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4820715/ https://ncbi.nlm.nih.gov/pubmed/27045335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24065 |
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