ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain

Carrying premature termination codons in 1 allele of the ABCA7 gene is associated with an increased risk for Alzheimer’s disease (AD). While the primary function of ABCA7 is to regulate the transport of phospholipids and cholesterol, ABCA7 is also involved in maintaining homeostasis of the immune sy...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Aikawa, Tomonori, Ren, Yingxue, Yamazaki, Yu, Tachibana, Masaya, Johnson, Madeleine R., Anderson, Casey T., Martens, Yuka A., Holm, Marie-Louise, Asmann, Yan W., Saito, Takashi, Saido, Takaomi C., Fitzgerald, Michael L., Bu, Guojun, Kanekiyo, Takahisa
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876254/
https://ncbi.nlm.nih.gov/pubmed/31690660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908529116
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