ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain

Carrying premature termination codons in 1 allele of the ABCA7 gene is associated with an increased risk for Alzheimer’s disease (AD). While the primary function of ABCA7 is to regulate the transport of phospholipids and cholesterol, ABCA7 is also involved in maintaining homeostasis of the immune sy...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Aikawa, Tomonori, Ren, Yingxue, Yamazaki, Yu, Tachibana, Masaya, Johnson, Madeleine R., Anderson, Casey T., Martens, Yuka A., Holm, Marie-Louise, Asmann, Yan W., Saito, Takashi, Saido, Takaomi C., Fitzgerald, Michael L., Bu, Guojun, Kanekiyo, Takahisa
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876254/
https://ncbi.nlm.nih.gov/pubmed/31690660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908529116
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