ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain

Carrying premature termination codons in 1 allele of the ABCA7 gene is associated with an increased risk for Alzheimer’s disease (AD). While the primary function of ABCA7 is to regulate the transport of phospholipids and cholesterol, ABCA7 is also involved in maintaining homeostasis of the immune sy...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Aikawa, Tomonori, Ren, Yingxue, Yamazaki, Yu, Tachibana, Masaya, Johnson, Madeleine R., Anderson, Casey T., Martens, Yuka A., Holm, Marie-Louise, Asmann, Yan W., Saito, Takashi, Saido, Takaomi C., Fitzgerald, Michael L., Bu, Guojun, Kanekiyo, Takahisa
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876254/
https://ncbi.nlm.nih.gov/pubmed/31690660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908529116
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