ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain

Carrying premature termination codons in 1 allele of the ABCA7 gene is associated with an increased risk for Alzheimer’s disease (AD). While the primary function of ABCA7 is to regulate the transport of phospholipids and cholesterol, ABCA7 is also involved in maintaining homeostasis of the immune sy...

詳細記述

保存先:
書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Aikawa, Tomonori, Ren, Yingxue, Yamazaki, Yu, Tachibana, Masaya, Johnson, Madeleine R., Anderson, Casey T., Martens, Yuka A., Holm, Marie-Louise, Asmann, Yan W., Saito, Takashi, Saido, Takaomi C., Fitzgerald, Michael L., Bu, Guojun, Kanekiyo, Takahisa
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2019
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876254/
https://ncbi.nlm.nih.gov/pubmed/31690660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908529116
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