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Peptide-nucleotide Antibiotic Microcin C Is a Potent Inducer of Stringent Response and Persistence in Both Sensitive and Producing Cells
Microcin C (McC) is a peptide-nucleotide antibiotic that inhibits aspartyl-tRNA synthetase. Here, we show that McC is a strong inducer of persistence in Escherichia coli. Persistence induced by McC is mediated by (p)ppGpp and requires chromosomally encoded toxin-antitoxin modules. McC-producing cell...
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| Publicado no: | Mol Microbiol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6876116/ https://ncbi.nlm.nih.gov/pubmed/28164379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13640 |
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