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Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases
The model organism Escherichia coli codes for at least 11 type II toxin–antitoxin (TA) modules, all implicated in bacterial persistence (multidrug tolerance). Ten of these encode messenger RNA endonucleases (mRNases) inhibiting translation by catalytic degradation of mRNA, and the 11th module, hipBA...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4413331/ https://ncbi.nlm.nih.gov/pubmed/25848049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423536112 |
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