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Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases
The model organism Escherichia coli codes for at least 11 type II toxin–antitoxin (TA) modules, all implicated in bacterial persistence (multidrug tolerance). Ten of these encode messenger RNA endonucleases (mRNases) inhibiting translation by catalytic degradation of mRNA, and the 11th module, hipBA...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4413331/ https://ncbi.nlm.nih.gov/pubmed/25848049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423536112 |
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