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The C-Terminal Part of Microcin B Is Crucial for DNA Gyrase Inhibition and Antibiotic Uptake by Sensitive Cells

Microcin B (McB) is a ribosomally synthesized antibacterial peptide. It contains up to nine oxazole and thiazole heterocycles that are introduced posttranslationally and are required for activity. McB inhibits the DNA gyrase, a validated drug target. Previous structure-activity analyses indicated th...

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Detalhes bibliográficos
Main Authors: Shkundina, Irina, Serebryakova, Marina, Severinov, Konstantin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993328/
https://ncbi.nlm.nih.gov/pubmed/24563033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00015-14
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