A Major Portion of DNA Gyrase Inhibitor Microcin B17 Undergoes an N,O-Peptidyl Shift during Synthesis

Microcin B17 (McB) is a 43-amino acid antibacterial peptide targeting the DNA gyrase. The McB precursor is ribosomally produced and then post-translationally modified by the McbBCD synthase. Active mature McB contains eight oxazole and thiazole heterocycles. Here, we show that a major portion of mat...

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Bibliografiske detaljer
Main Authors: Ghilarov, Dmitry, Serebryakova, Marina, Shkundina, Irina, Severinov, Konstantin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143593/
https://ncbi.nlm.nih.gov/pubmed/21628468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.241315
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