Expanded Physiologically‐Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction

As rifampicin can cause the induction and inhibition of multiple metabolizing enzymes and transporters, it has been challenging to accurately predict the complex drug–drug interactions (DDIs). We previously constructed a physiologically‐based pharmacokinetic (PBPK) model of rifampicin accounting for...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:CPT Pharmacometrics Syst Pharmacol
Päätekijät: Asaumi, Ryuta, Menzel, Karsten, Lee, Wooin, Nunoya, Ken‐ichi, Imawaka, Haruo, Kusuhara, Hiroyuki, Sugiyama, Yuichi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2019
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6875706/
https://ncbi.nlm.nih.gov/pubmed/31420941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12457
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