Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization

Glaucoma is characterized by a progressive optic nerve degeneration and retinal ganglion cell loss, but the underlying biological basis for the accompanying neurodegeneration is not known. Accumulating evidence indicates that structural and functional abnormalities of astrocytes within the optic ner...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Ju, Won-Kyu, Shim, Myoung Sup, Kim, Keun-Young, Park, Tae Lim, Ahn, Sangphil, Edwards, Genea, Weinreb, Robert N.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6875302/
https://ncbi.nlm.nih.gov/pubmed/31781352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/8060962
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