Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization

Glaucoma is characterized by a progressive optic nerve degeneration and retinal ganglion cell loss, but the underlying biological basis for the accompanying neurodegeneration is not known. Accumulating evidence indicates that structural and functional abnormalities of astrocytes within the optic ner...

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Bibliographic Details
Published in:Oxid Med Cell Longev
Main Authors: Ju, Won-Kyu, Shim, Myoung Sup, Kim, Keun-Young, Park, Tae Lim, Ahn, Sangphil, Edwards, Genea, Weinreb, Robert N.
Format: Artigo
Language:Inglês
Published: Hindawi 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6875302/
https://ncbi.nlm.nih.gov/pubmed/31781352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/8060962
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