Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes

Glaucoma is characterized by a progressive loss of retinal ganglion cells and their axons, but the underlying biological basis for the accompanying neurodegeneration is not known. Accumulating evidence indicates that structural and functional abnormalities of astrocytes within the optic nerve head (...

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Pubblicato in:Cell Death Dis
Autori principali: Shim, Myoung Sup, Kim, Keun-Young, Bu, Jung Hyun, Nam, Hye Seung, Jeong, Seung Won, Park, Tae Lim, Ellisman, Mark H., Weinreb, Robert N., Ju, Won-Kyu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833440/
https://ncbi.nlm.nih.gov/pubmed/29459737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0171-8
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