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Targeting L-Lactate Metabolism to Overcome Resistance to Immune Therapy of Melanoma and Other Tumor Entities

Although immunotherapy plays a significant role in tumor therapy, its efficacy is impaired by an immunosuppressive tumor microenvironment. A molecule that contributes to the protumor microenvironment is the metabolic product lactate. Lactate is produced in large amounts by cancer cells in response t...

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Detalhes bibliográficos
Publicado no:J Oncol
Main Authors: Feichtinger, René G., Lang, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6875281/
https://ncbi.nlm.nih.gov/pubmed/31781212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/2084195
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