Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1

Immune checkpoint inhibitors (ICIs) have dramatically modified the prognosis of several advanced cancers, however many patients still do not respond to treatment. Optimal results might be obtained by targeting cancer cell metabolism to modulate the immunosuppressive tumor microenvironment. Here, we...

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Publicado no:Nat Commun
Main Authors: Imbert, Caroline, Montfort, Anne, Fraisse, Marine, Marcheteau, Elie, Gilhodes, Julia, Martin, Elodie, Bertrand, Florie, Marcellin, Marlène, Burlet-Schiltz, Odile, Peredo, Anne Gonzalez de, Garcia, Virginie, Carpentier, Stéphane, Tartare-Deckert, Sophie, Brousset, Pierre, Rochaix, Philippe, Puisset, Florent, Filleron, Thomas, Meyer, Nicolas, Lamant, Laurence, Levade, Thierry, Ségui, Bruno, Andrieu-Abadie, Nathalie, Colacios, Céline
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978345/
https://ncbi.nlm.nih.gov/pubmed/31974367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14218-7
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