Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs

A fundamental challenge in chemical biology and medicine is to understand and expand the fraction of the human proteome that can be targeted by small molecules. We recently described a strategy that integrates fragment-based ligand discovery with chemical proteomics to furnish global portraits of re...

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Vydáno v:Nat Chem
Hlavní autoři: Wang, Yujia, Dix, Melissa M., Bianco, Giulia, Remsberg, Jarrett R., Lee, Hsin-Yu, Kalocsay, Marian, Gygi, Steven P., Forli, Stefano, Vite, Gregory, Lawrence, R. Michael, Parker, Christopher G., Cravatt, Benjamin F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874898/
https://ncbi.nlm.nih.gov/pubmed/31659311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-019-0351-5
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