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Lowering the culture temperature corrects collagen abnormalities caused by HSP47 gene knockout
Heat shock protein 47 (HSP47) is an endoplasmic reticulum (ER)-resident molecular chaperone that specifically recognizes triple helical portions of procollagens. The chaperone function of HSP47 is indispensable in mammals, and hsp47-null mice show an embryonic lethal phenotype accompanied by severe...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6874656/ https://ncbi.nlm.nih.gov/pubmed/31758055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53962-0 |
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