Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva‐Derived Endothelial Cells

Fibrodysplasia ossificans progressiva (FOP) is an extremely rare congenital form of heterotopic ossification (HO), caused by heterozygous mutations in the activin A type I receptor (ACVR1), that encodes the bone morphogenetic protein (BMP) type I receptor ALK2. These mutations enable ALK2 to induce...

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Vydáno v:JBMR Plus
Hlavní autoři: Sánchez‐Duffhues, Gonzalo, Williams, Eleanor, Benderitter, Pascal, Orlova, Valeria, van Wijhe, Michiel, Garcia de Vinuesa, Amaya, Kerr, Georgina, Caradec, Josselin, Lodder, Kirsten, de Boer, Hetty C., Goumans, Marie‐José, Eekhoff, Elisabeth M W, Morales‐Piga, Antonio, Bachiller‐Corral, Javier, Koolwijk, Pieter, Bullock, Alex N., Hoflack, Jan, ten Dijke, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2019
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874179/
https://ncbi.nlm.nih.gov/pubmed/31768489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm4.10230
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