Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva

Fibrodysplasia ossificans progressiva (FOP) is a rare disease characterized by progressive ossification of soft tissues, for which there is no effective treatment. Mutations in the bone morphogenetic protein (BMP) type I receptor activin receptor-like kinase 2 (ACVR1/ALK2) are the main cause of FOP....

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Udgivet i:Stem Cell Reports
Main Authors: Cai, Jie, Orlova, Valeria V., Cai, Xiujuan, Eekhoff, Elisabeth M.W., Zhang, Keqin, Pei, Duanqing, Pan, Guangjin, Mummery, Christine L., ten Dijke, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682290/
https://ncbi.nlm.nih.gov/pubmed/26626181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.10.020
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