Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva

Fibrodysplasia ossificans progressiva (FOP) is a rare disease characterized by progressive ossification of soft tissues, for which there is no effective treatment. Mutations in the bone morphogenetic protein (BMP) type I receptor activin receptor-like kinase 2 (ACVR1/ALK2) are the main cause of FOP....

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Hlavní autoři: Jie Cai, Valeria V. Orlova, Xiujuan Cai, Elisabeth M.W. Eekhoff, Keqin Zhang, Duanqing Pei, Guangjin Pan, Christine L. Mummery, Peter ten Dijke
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015-12-01
Edice:Stem Cell Reports
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2213671115003173
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