A piperidinol-containing molecule is active against Mycobacterium tuberculosis by inhibiting the mycolic acid flippase activity of MmpL3

Mycobacterium tuberculosis, the causative agent of tuberculosis, remains a major human pathogen, and current treatment options to combat this disease are under threat because of the emergence of multidrug-resistant and extensively drug-resistant tuberculosis. High-throughput whole-cell screening of...

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Vydáno v:J Biol Chem
Hlavní autoři: Dupont, Christian, Chen, Yushu, Xu, Zhujun, Roquet-Banères, Françoise, Blaise, Mickaël, Witt, Anne-Kathrin, Dubar, Faustine, Biot, Christophe, Guérardel, Yann, Maurer, Florian P., Chng, Shu-Sin, Kremer, Laurent
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6873192/
https://ncbi.nlm.nih.gov/pubmed/31562241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010135
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