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The pseudosubstrate inhibitor Acm1 inhibits the anaphase-promoting complex/cyclosome by combining high-affinity activator binding with disruption of Doc1/Apc10 function

The anaphase-promoting complex/cyclosome (APC/C) is a large, multisubunit ubiquitin ligase involved in regulation of cell division. APC/C substrate specificity arises from binding of short degron motifs in its substrates to transient activator subunits, Cdc20 and Cdh1. The destruction box (D-box) is...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Qin, Liang, Mizrak, Arda, Guimarães, Dimitrius Santiago P. S. F., Tambrin, Hana M., Morgan, David O., Hall, Mark C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6873173/
https://ncbi.nlm.nih.gov/pubmed/31562243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009468
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