Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

OBJECTIVE: The colonic inner mucus layer protects us from pathogens and commensal-induced inflammation, and has been shown to be defective in active UC. The aim of this study was to determine the underlying compositional alterations, their molecular background and potential contribution to UC pathog...

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Detalles Bibliográficos
Publicado en:Gut
Main Authors: van der Post, Sjoerd, Jabbar, Karolina S, Birchenough, George, Arike, Liisa, Akhtar, Noreen, Sjovall, Henrik, Johansson, Malin E V, Hansson, Gunnar C
Formato: Artigo
Idioma:Inglês
Publicado: BMJ Publishing Group 2019
Assuntos:
Inflammatory Bowel Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6872445/
https://ncbi.nlm.nih.gov/pubmed/30914450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2018-317571
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