Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

OBJECTIVE: The inner mucus layer in mouse colon normally separates bacteria from the epithelium. Do humans have a similar inner mucus layer and are defects in this mucus layer a common denominator for spontaneous colitis in mice models and ulcerative colitis (UC)? METHODS AND RESULTS: The colon mucu...

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Detalhes bibliográficos
Main Authors: Johansson, Malin E V, Gustafsson, Jenny K, Holmén-Larsson, Jessica, Jabbar, Karolina S, Xia, Lijun, Xu, Hua, Ghishan, Fayez K, Carvalho, Frederic A, Gewirtz, Andrew T, Sjövall, Henrik, Hansson, Gunnar C
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2014
Assuntos:
Inflammatory Bowel Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740207/
https://ncbi.nlm.nih.gov/pubmed/23426893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2012-303207
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