RAG-Mediated DNA Breaks Attenuate PU.1 Activity in Early B Cells through Activation of a SPIC-BCLAF1 Complex

Early B cell development is regulated by stage-specific transcription factors. PU.1, an ETS-family transcription factor, is essential for coordination of early B cell maturation and immunoglobulin gene (Ig) rearrangement. Here we show that RAG DNA double-strand breaks (DSBs) generated during Ig ligh...

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Udgivet i:Cell Rep
Main Authors: Soodgupta, Deepti, White, Lynn S., Yang, Wei, Johnston, Rachel, Andrews, Jared M., Kohyama, Masako, Murphy, Kenneth M., Mosammaparast, Nima, Payton, Jacqueline E., Bednarski, Jeffrey J.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6870970/
https://ncbi.nlm.nih.gov/pubmed/31644907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.09.026
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