SUMO3 modification by PIAS1 modulates androgen receptor cellular distribution and stability

BACKGROUND: Abnormal reactivation of androgen receptor (AR) signaling in castration-resistant prostate cancer (CRPC) mainly results from overexpression and down-regulation of AR. Sumoylation of AR can influence its function. However, regulation of AR sumoylation by SUMO E3 ligases PIASs to modify AR...

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Vydáno v:Cell Commun Signal
Hlavní autoři: Yang, Nanyang, Liu, Sitong, Qin, Tian, Liu, Xintong, Watanabe, Nobumoto, Mayo, Kevin H., Li, Jiang, Li, Xiaomeng
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868827/
https://ncbi.nlm.nih.gov/pubmed/31752909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0457-9
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