Simultaneous targeting of XPO1 and BCL2 as an effective treatment strategy for double-hit lymphoma

Double-hit lymphoma (DHL) is among the most aggressive and chemoresistant lymphoma subtypes. DHLs carry genomic abnormalities in MYC, BCL2, and/or BCL6 oncogenes. Due to the simultaneous overexpression of these driver oncogenes, DHLs are highly resistant to frontline therapies. Most DHLs overexpress...

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Detaylı Bibliyografya
Yayımlandı:J Hematol Oncol
Asıl Yazarlar: Liu, Yuanhui, Azizian, Nancy G., Dou, Yaling, Pham, Lan V., Li, Yulin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2019
Konular:
Rapid Communication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868798/
https://ncbi.nlm.nih.gov/pubmed/31752970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-019-0803-9
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