Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors

Double/triple-hit lymphomas (DHL/THL) account for 5–10% of diffuse large B cell lymphoma (DLBCL) with rearrangement of MYC and BCL2 and/or BCL6 resulting in MYC overexpression. Despite the poor prognosis of DHL, R-CHOP chemotherapy remains the treatment backbone and new targeted therapy is needed. W...

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Udgivet i:J Hematol Oncol
Main Authors: Li, Weiping, Gupta, Shiv K., Han, Weiguo, Kundson, Ryan A., Nelson, Sara, Knutson, Darlene, Greipp, Patricia T., Elsawa, Sherine F., Sotomayor, Eduardo M., Gupta, Mamta
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Rapid Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6617630/
https://ncbi.nlm.nih.gov/pubmed/31288832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-019-0761-2
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