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Simultaneous targeting of XPO1 and BCL2 as an effective treatment strategy for double-hit lymphoma
Double-hit lymphoma (DHL) is among the most aggressive and chemoresistant lymphoma subtypes. DHLs carry genomic abnormalities in MYC, BCL2, and/or BCL6 oncogenes. Due to the simultaneous overexpression of these driver oncogenes, DHLs are highly resistant to frontline therapies. Most DHLs overexpress...
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| Publicado no: | J Hematol Oncol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6868798/ https://ncbi.nlm.nih.gov/pubmed/31752970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-019-0803-9 |
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