Upregulation of IGF2R evades lysosomal dysfunction-induced apoptosis of cervical cancer cells via transport of cathepsins

Cervical cancer is the most common gynecological malignancy in the world; however, the survival rates of advanced-stage and recurrent cervical cancer patients remain poor. The multifaced protein insulin-like growth factor 2 receptor (IGF2R) has various ligands, represented as IGF-2 and mannose-6-pho...

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Pubblicato in:Cell Death Dis
Autori principali: Takeda, Takashi, Komatsu, Masayuki, Chiwaki, Fumiko, Komatsuzaki, Rie, Nakamura, Kanako, Tsuji, Kosuke, Kobayashi, Yusuke, Tominaga, Eiichiro, Ono, Masaya, Banno, Kouji, Aoki, Daisuke, Sasaki, Hiroki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868013/
https://ncbi.nlm.nih.gov/pubmed/31748500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-2117-9
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