Constitutive AKT Activity Predisposes Lung Fibrosis by Regulating Macrophage, Myofibroblast and Fibrocyte Recruitment and Changes in Autophagy

The etiology and pathogenesis of pulmonary fibrosis is poorly understood. We and others reported that M-CSF/CSF-1, M-CSF-R and downstream AKT activation plays an important role in lung fibrosis in mice models and in IPF patients. To understand potential molecular pathways used by M-CSF-R activation...

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Detalhes bibliográficos
Publicado no:Adv Biosci Biotechnol
Main Authors: Dakhlallah, Duaa, Wang, Yijie, Bobo, Tierra A., Ellis, Emily, Mo, Xiaokui, Piper, Melissa G., Eubank, Timothy D., Marsh, Clay B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6866236/
https://ncbi.nlm.nih.gov/pubmed/31750010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4236/abb.2019.1010027
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