Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X

The human ATPase/RNA helicase X-linked DEAD-box polypeptide 3 (DDX3X) emerged as a novel therapeutic target in the fight against both infectious diseases and cancer. Herein, a new family of DDX3X inhibitors was designed, synthesized, and tested for its inhibitory action on the ATPase activity of the...

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Vydáno v:Molecules
Hlavní autoři: Brai, Annalaura, Ronzini, Stefania, Riva, Valentina, Botta, Lorenzo, Zamperini, Claudio, Borgini, Matteo, Trivisani, Claudia Immacolata, Garbelli, Anna, Pennisi, Carla, Boccuto, Adele, Saladini, Francesco, Zazzi, Maurizio, Maga, Giovanni, Botta, Maurizio
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6864647/
https://ncbi.nlm.nih.gov/pubmed/31690062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24213988
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