Temporal perturbation of ERK dynamics reveals network architecture of FGF2/MAPK signaling

Stimulation of PC‐12 cells with epidermal (EGF) versus nerve (NGF) growth factors (GFs) biases the distribution between transient and sustained single‐cell ERK activity states, and between proliferation and differentiation fates within a cell population. We report that fibroblast GF (FGF2) evokes a...

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Detalhes bibliográficos
Publicado no:Mol Syst Biol
Main Authors: Blum, Yannick, Mikelson, Jan, Dobrzyński, Maciej, Ryu, Hyunryul, Jacques, Marc‐Antoine, Jeon, Noo Li, Khammash, Mustafa, Pertz, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Methods
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6864398/
https://ncbi.nlm.nih.gov/pubmed/31777174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20198947
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