Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo

Recently, the targeting of ERK with ATP-competitive inhibitors has emerged as a potential clinical strategy to overcome acquired resistance to BRAF and MEK inhibitor combination therapies. In this study, we investigate an alternative strategy of targeting the D-recruitment site (DRS) of ERK. The DRS...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kaoud, Tamer S., Johnson, William H., Ebelt, Nancy D., Piserchio, Andrea, Zamora-Olivares, Diana, Van Ravenstein, Sabrina X., Pridgen, Jacey R., Edupuganti, Ramakrishna, Sammons, Rachel, Cano, Micael, Warthaka, Mangalika, Harger, Matthew, Tavares, Clint D. J., Park, Jihyun, Radwan, Mohamed F., Ren, Pengyu, Anslyn, Eric V., Tsai, Kenneth Y., Ghose, Ranajeet, Dalby, Kevin N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863825/
https://ncbi.nlm.nih.gov/pubmed/31745079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12996-8
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