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Allosteric discrimination at the NADH/ADP regulatory site of glutamate dehydrogenase
Glutamate dehydrogenase (GDH) is a target for treating insulin‐related disorders, such as hyperinsulinism hyperammonemia syndrome. Modeling native ligand binding has shown promise in designing GDH inhibitors and activators. Our computational investigation of the nicotinamide adenine diphosphate hydr...
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| Udgivet i: | Protein Sci |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley & Sons, Inc.
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6863735/ https://ncbi.nlm.nih.gov/pubmed/31610054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3748 |
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