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Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3
Although the process of autophagy has been extensively studied, the mechanisms that regulate it remain insufficiently understood. To identify novel autophagy regulators, we performed a whole-genome CRISPR/Cas9 knockout screen in H4 human neuroglioma cells expressing endogenous LC3B tagged with a tan...
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| Published in: | eLife |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
eLife Sciences Publications, Ltd
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6863627/ https://ncbi.nlm.nih.gov/pubmed/31692446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50034 |
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