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Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3

Although the process of autophagy has been extensively studied, the mechanisms that regulate it remain insufficiently understood. To identify novel autophagy regulators, we performed a whole-genome CRISPR/Cas9 knockout screen in H4 human neuroglioma cells expressing endogenous LC3B tagged with a tan...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Jia, Rui, Bonifacino, Juan S
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863627/
https://ncbi.nlm.nih.gov/pubmed/31692446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50034
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