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The E3 ubiquitin ligase NEDD4 is an LC3-interactive protein and regulates autophagy
The MAP1LC3/LC3 family plays an essential role in autophagosomal biogenesis and transport. In this report, we show that the HECT family E3 ubiquitin ligase NEDD4 interacts with LC3 and is involved in autophagosomal biogenesis. NEDD4 binds to LC3 through a conserved WXXL LC3-binding motif in a region...
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| Udgivet i: | Autophagy |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5361608/ https://ncbi.nlm.nih.gov/pubmed/28085563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1268301 |
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