The E3 ubiquitin ligase NEDD4 is an LC3-interactive protein and regulates autophagy

The MAP1LC3/LC3 family plays an essential role in autophagosomal biogenesis and transport. In this report, we show that the HECT family E3 ubiquitin ligase NEDD4 interacts with LC3 and is involved in autophagosomal biogenesis. NEDD4 binds to LC3 through a conserved WXXL LC3-binding motif in a region...

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Detalles Bibliográficos
Publicado en:Autophagy
Autores principales: Sun, Aiqin, Wei, Jing, Childress, Chandra, Shaw, John H., Peng, Ke, Shao, Genbao, Yang, Wannian, Lin, Qiong
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2017
Materias:
Basic Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361608/
https://ncbi.nlm.nih.gov/pubmed/28085563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1268301
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