The E3 ubiquitin ligase NEDD4 is an LC3-interactive protein and regulates autophagy

The MAP1LC3/LC3 family plays an essential role in autophagosomal biogenesis and transport. In this report, we show that the HECT family E3 ubiquitin ligase NEDD4 interacts with LC3 and is involved in autophagosomal biogenesis. NEDD4 binds to LC3 through a conserved WXXL LC3-binding motif in a region...

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Bibliografische gegevens
Gepubliceerd in:Autophagy
Hoofdauteurs: Sun, Aiqin, Wei, Jing, Childress, Chandra, Shaw, John H., Peng, Ke, Shao, Genbao, Yang, Wannian, Lin, Qiong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2017
Onderwerpen:
Basic Research Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361608/
https://ncbi.nlm.nih.gov/pubmed/28085563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1268301
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