Anesthetic Agents Isoflurane and Propofol Decrease Maximal Ca(2+)-Activated Force and Thus Contractility in the Failing Myocardium

In the normal heart, frequently used anesthetics such as isoflurane and propofol can reduce inotropy. However, the impact of these agents on the failing myocardium is unclear. Here, we examined whether and how isoflurane and propofol influence cardiac contractility in intact cardiac muscles from rat...

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Veröffentlicht in:J Pharmacol Exp Ther
Hauptverfasser: Meng, Tao, Ren, Xianfeng, Chen, Xinzhong, Yu, Jingui, Agrimi, Jacopo, Paolocci, Nazareno, Gao, Wei Dong
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2019
Schlagworte:
Cardiovascular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863458/
https://ncbi.nlm.nih.gov/pubmed/31515443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.259556
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