Anesthetic Agents Isoflurane and Propofol Decrease Maximal Ca(2+)-Activated Force and Thus Contractility in the Failing Myocardium

In the normal heart, frequently used anesthetics such as isoflurane and propofol can reduce inotropy. However, the impact of these agents on the failing myocardium is unclear. Here, we examined whether and how isoflurane and propofol influence cardiac contractility in intact cardiac muscles from rat...

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Pubblicato in:J Pharmacol Exp Ther
Autori principali: Meng, Tao, Ren, Xianfeng, Chen, Xinzhong, Yu, Jingui, Agrimi, Jacopo, Paolocci, Nazareno, Gao, Wei Dong
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2019
Soggetti:
Cardiovascular
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863458/
https://ncbi.nlm.nih.gov/pubmed/31515443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.259556
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