UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

Although clonal neo-antigen burden is associated with improved response to immune therapy, the functional basis for this remains unclear. Here we study this question in a novel controlled mouse melanoma model that enables us to explore the effects of intra-tumor heterogeneity (ITH) on tumor aggressi...

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Publicat a:Cell
Autors principals: Wolf, Yochai, Bartok, Osnat, Patkar, Sushant, Eli, Gitit Bar, Cohen, Sapir, Litchfield, Kevin, Levy, Ronen, Jiménez-Sánchez, Alejandro, Trabish, Sophie, Lee, Joo Sang, Karathia, Hiren, Barnea, Eilon, Day, Chi-Ping, Cinnamon, Einat, Stein, Ilan, Solomon, Adam, Bitton, Lital, Pérez-Guijarro, Eva, Dubovik, Tania, Shen-Orr, Shai S., Miller, Martin L., Merlino, Glenn, Levin, Yishai, Pikarsky, Eli, Eisenbach, Lea, Admon, Arie, Swanton, Charles, Ruppin, Eytan, Samuels, Yardena
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863386/
https://ncbi.nlm.nih.gov/pubmed/31522890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.08.032
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