Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

Failure to make adaptive immune responses is a hallmark of aging. Reduced B cell function leads to poor vaccination efficacy and a high prevalence of infections in the elderly. Here we show that reduced autophagy is a central molecular mechanism underlying immune senescence. Autophagy levels are spe...

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Gepubliceerd in:Mol Cell
Hoofdauteurs: Zhang, Hanlin, Alsaleh, Ghada, Feltham, Jack, Sun, Yizhe, Napolitano, Gennaro, Riffelmacher, Thomas, Charles, Philip, Frau, Lisa, Hublitz, Philip, Yu, Zhanru, Mohammed, Shabaz, Ballabio, Andrea, Balabanov, Stefan, Mellor, Jane, Simon, Anna Katharina
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863385/
https://ncbi.nlm.nih.gov/pubmed/31474573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.08.005
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